We all know how bad viruses are.
From common cold to the deadly AIDS, they affect us in many ways. But it is
amazing and startling to know the fact that they have played a crucial role in
our (human) life cycle. If not for these certain viruses, we would be hatching
out of eggs like birds or reptiles. In the year 2000, a group of scientists
from Genetics Institute Inc., Cambridge, Massachusetts identified a new human gene
that expresses a protein called syncytin. Though Syncytin gene is a part of
human genome now, it has been incorporated there by viruses. This original
viral protein would be expressed by the invading virus to spread along the host
body and cause infection. However, the protein served a different function for
the human or more precisely mammals by forming placenta. Placenta is the
connecting tube between a growing fetus and the mother’s uterus which serves
nutrient uptake and ensures fetal development. It is believed that human or mammalian
placentae are formed by fusion of the cytotrophoblast cells through expression
of syncytin. If there were no viral gene syncytin, there would have been no
placenta formation. Several forms of syncytin are being discovered in different
mammalian species piecing together the story of evolution. Not just syncytin, there are several other genes that make up the human DNA accounting for atleast 8% of human DNA.
Welcome to my Sciblog! Get to know the latest fascinating discoveries and medical innovations in a simple and lucid language.
Monday, February 20, 2012
Wednesday, February 1, 2012
Drug for a genetic disease - more and more are sure to come.
Cystic fibrosis causes the body to produce an
unusually thick, sticky mucus that clogs the lungs and obstructs the pancreas
and stops enzymes from helping the body break down and absorb food. These patients
are prone to infections and progressively lose the ability to breathe.
The disease is caused by genetic mutations in a gene called cystic fibrosis
transmembrane conductance regulator (CFTR) which regulates the transport
of chloride and water in the body. The US Food and Drug Administration has
approved "the first therapy to treat an underlying cause of cystic
fibrosis”. The drug targets the most common mutation in the gene and restores the function (of CFTR protein) and not the symptoms of it. Approximately 4% of cystic fibrosis patients can be benefitted from
this expensive therapy costing $294,000 a year.
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